Onosma bracteatum, commonly known as "Gaozaban," has a long history of use in traditional Unani and Ayurvedic medicine, particularly in South Asia. It is considered a "hepatoprotective" herb within these systems and is included in polyherbal formulations aimed at liver ailments, including hepatitis. Traditional texts and Unani practitioners describe its use for "cooling" the liver, reducing inflammation, and alleviating symptoms associated with hepatitis such as jaundice and liver discomfort. The plant is believed to possess anti-inflammatory, antioxidant, and demulcent properties, which are thought to be beneficial for liver health.

Scientific validation for its use in hepatitis is limited. There are a few in vitro and animal studies suggesting hepatoprotective effects, but these are preliminary and often not specific to human hepatitis. No robust clinical trials have been conducted to confirm efficacy in hepatitis patients. Most evidence remains anecdotal or based on traditional practice rather than rigorous research. As a result, while Onosma bracteatum is traditionally used for supporting liver health and hepatitis, the scientific evidence supporting this use is weak to moderate (rated 2 out of 5), largely relying on traditional knowledge rather than high-quality clinical data.