Evidence supporting the use of: Ornithine L-aspartic acid
For the health condition: Hepatitis
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Ornithine l-aspartic acid (LOLA) is supported by scientific evidence for its use in the management of hepatic encephalopathy, a complication of advanced liver disease such as hepatitis. LOLA is a combination of the amino acids ornithine and aspartic acid, which play roles in the urea cycle and ammonia detoxification. Elevated blood ammonia levels are a key factor in the development of hepatic encephalopathy in patients with chronic liver diseases, including those caused by hepatitis.
Clinical studies and meta-analyses have shown that LOLA administration can significantly reduce blood ammonia concentrations and improve mental status in patients with hepatic encephalopathy. The drug works by enhancing the conversion of ammonia to urea in the liver, and to glutamine in skeletal muscle, thereby facilitating ammonia removal from the bloodstream. The European Association for the Study of the Liver guidelines mention LOLA as a therapeutic option for hepatic encephalopathy.
However, while LOLA is effective for hepatic encephalopathy, direct evidence supporting its use to treat hepatitis itself (i.e., to reduce liver inflammation or viral replication) is limited. Its use in hepatitis is primarily to manage the metabolic complications (like hyperammonemia) arising from impaired liver function, rather than to treat the underlying hepatic inflammation or viral infection. Thus, its use in hepatitis is justified as supportive therapy for complications, not as a primary treatment for the disease itself.
Other ingredients used for Hepatitis
AchyranthesAerva lanata
Agrimonia pilosa
AHCC
Ajuga
Albumin
Algae
American Liverleaf
Andrographis
andrographolide
Angelica
Antrodia camphorata
aster root
astragalin
astragaloside
astragalus
atractylone
aucubin
Auricularia
Baccharoides anthelmintica
bacteria
bael
baicalin
Basidiomycota
Bassia scoparia
bayleaf
BCAA
Bergenia
bergenin
betulinic acid
bitter grass
black cumin
black root
black seed
blackboard tree
Bombax
Borassus aethiopum
borassus palm
borotutu
branched-chain amino acids
Broussonetia
Bupleurum
bupleurum falcatum
burdock
C-phycocyanin
Caesalpinia crista
Carthamus
cat's claw
caterpillar mushroom
Celosia
chaga mushroom
Chinese fleeceflower
Chinese silkvine
chirata
Clerodendrum indicum
commiphora
Coptis chinensis
cordyceps
corilagin
coriolus mushroom
Cynodon dactylon
cytokines
dandelion
Desmodium
Dianthus
Ficus simplicissima
flat-stem milk-vetch
flavonolignan
Flueggea suffruticosa
fucoidan
ganoderma
Globulins
Glucan peptides
Glutathione
Glycyrrhetinic acid
Glycyrrhizin
green chiretta
Hygrophila
Hyperoside
Immunoglobulin G
Indian bael
Indian coraltree
isosilybin
jujube
knotweed
L-cysteine
L-glutathione
labrador tea
Lactoferrin
Lentinula edodes mycelia
lichen
licorice root
Ligustrum
lingzhi
liquid liver fractions
little ironweed
Marine lipid
Milk thistle
Momordica
Morning glory
Morus
Myrrh
N-acetyl-cysteine (NAC)
Neoandrographolides
Nymphaea nouchali
oleanolic acid
omega-3 fatty acids
Onosma bracteatum
oregon grape
ornithine L-aspartic acid
Oroxylum indicum
Oxymatrine
pagoda tree
Palo Azul
parsley
Patrinia
paw paw
peony
Phellodendron
Picroside
Pluchea
plum fruit
Polygonum
polysaccharides
Portulaca
prebiotic blend (proprietary)
protein
punarnava
reishi mushroom
rhubarb
rice
Rubia cordifolia
Rubia yunnanensis
Sarivan
sarsaparilla
Schisandrins
Schizandrol A
seaweed
selenium
shiitake mushroom
Silybin
Silybum
Silychristin
Silydianin
silymarin
Sophora
spirulina
Stereospermum
Sulfated polysaccharide
Sumac
Swertia
Sword Bean
Szechuan lovage
Tamarind
Taraxacum
Terminalia
Tinospora cordifolia
Trametes
Tremella
Turkey tail mushroom
turmeric
Varuna
vitamin C
vitamin E
Wax Gourd
Yin Chen
Zinc
Zucchini
Other health conditions supported by ornithine L-aspartic acid
AlcoholismCirrhosis of the Liver
Energy (lack of)
Fatigue
Fatty Liver Disease
Hepatitis
Liver Detoxification