Evidence supporting the use of: Pentacyclic Oxindole Alkaloids
For the health condition: Hepatitis

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Pentacyclic oxindole alkaloids are primarily found in the Uncaria tomentosa plant, commonly known as Cat’s Claw. The traditional use of Cat’s Claw, especially in South American indigenous medicine, includes the treatment of various inflammatory and infectious diseases, including liver ailments like hepatitis. The rationale for its use in hepatitis is largely based on its purported anti-inflammatory and immunomodulating properties, rather than direct antiviral activity.

Scientific studies on pentacyclic oxindole alkaloids have demonstrated some immunoregulatory effects, such as modulation of cytokine production and antioxidant activity. However, clinical evidence specifically supporting their efficacy in the treatment of hepatitis (either viral or non-viral forms) is very limited. Most available studies are in vitro or in animal models, and these do not directly translate to proven benefits in human hepatitis patients. There are no robust randomized controlled trials or systematic reviews supporting its use in hepatitis treatment.

In summary, the use of pentacyclic oxindole alkaloids for hepatitis is rooted in traditional medicine practices, with only weak preclinical evidence suggesting possible benefit. It cannot be considered scientifically validated for this indication at present.

More about Pentacyclic Oxindole Alkaloids
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Products containing Pentacyclic Oxindole Alkaloids

We currently have no products on Vitabase that contain this ingredient.