Evidence supporting the use of: Rhubarb
For the health condition: Hepatitis

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Rhubarb (Rheum palmatum and related species) has been used in traditional Chinese medicine (TCM) for centuries, including as a remedy for liver disorders such as hepatitis. In TCM, rhubarb is valued for its ability to "clear heat," "remove toxins," and "invigorate blood circulation," which are believed to support liver health and function. Historical records and classical TCM texts document its use in herbal formulas for treating symptoms associated with hepatitis, such as jaundice and abdominal discomfort.

However, modern scientific evidence supporting rhubarb’s efficacy for hepatitis is limited and primarily preclinical. Some animal and in vitro studies suggest that certain rhubarb constituents—such as anthraquinones (e.g., emodin)—may have anti-inflammatory, antioxidant, and hepatoprotective effects. These findings have prompted further interest in rhubarb as a potential adjunct for liver diseases. Nonetheless, robust clinical trials in humans are lacking, and safety concerns exist due to rhubarb’s potent laxative effect and potential nephrotoxicity with long-term use.

In summary, rhubarb's use for hepatitis is justified mostly by traditional practice, and while some preliminary scientific data exist, the overall quality and quantity of clinical evidence are low. It should not be relied upon as a primary treatment for hepatitis without medical supervision.

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