Sarsaparilla (Smilax spp.) has a long history of use in traditional medicine, particularly in South America, Asia, and Europe. In these traditional systems, sarsaparilla roots were used as a general "blood purifier," for treating skin conditions, and sometimes for liver-related ailments, including hepatitis. The rationale for its use in hepatitis stemmed from its reputation as a detoxifying agent and its presumed ability to support liver function.

However, scientific evidence directly supporting sarsaparilla's benefits for hepatitis is scant. Most modern research has focused on its anti-inflammatory, antioxidant, and antimicrobial properties, with only a few preliminary studies suggesting that some compounds in sarsaparilla (like sarsaponin and related phytochemicals) might have liver-protective effects in vitro or in animal models. There are no robust clinical trials demonstrating efficacy or safety for hepatitis treatment in humans.

Thus, while traditional use for liver health and possibly hepatitis exists, the evidence is extremely limited and largely anecdotal. Most modern clinicians do not recommend sarsaparilla as a treatment for hepatitis due to the lack of convincing scientific validation. Anyone considering its use for this purpose should consult a healthcare professional.