Evidence supporting the use of: Vitamin E (vitamin E acetate)
For the health condition: Hepatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (specifically vitamin E acetate) has been studied for its potential role in supporting or treating certain types of hepatitis, particularly nonalcoholic steatohepatitis (NASH), a severe form of nonalcoholic fatty liver disease (NAFLD). The scientific evidence for its use in other forms of hepatitis, such as viral hepatitis (hepatitis B or C), is limited or inconclusive.

The rationale for using vitamin E lies in its antioxidant properties, which may help reduce oxidative stress and liver cell injury implicated in NASH. The most notable clinical trial is the PIVENS trial (published in the New England Journal of Medicine, 2010), a randomized, placebo-controlled study in non-diabetic adults with NASH. The study found that 800 IU/day of vitamin E led to significant improvements in liver histology compared with placebo, specifically in steatosis and inflammation, but not in fibrosis.

Based on such evidence, the American Association for the Study of Liver Diseases (AASLD) recommends vitamin E as a treatment option for non-diabetic adults with biopsy-proven NASH. However, for viral hepatitis or other types of liver inflammation, there is insufficient scientific evidence supporting vitamin E supplementation as an effective therapy. Thus, while there is scientific support for vitamin E in certain hepatitis contexts (notably NASH), the overall strength of evidence is moderate, and its use is not broadly validated for all forms of hepatitis.

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