Evidence supporting the use of: Eugenol
For the health condition: Herpes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eugenol, a major constituent of clove oil, has been investigated for its antiviral properties, including potential effects against herpes simplex virus (HSV). Several in vitro (test tube) studies have demonstrated that eugenol can inhibit the replication of HSV-1 and HSV-2, the viruses responsible for oral and genital herpes, respectively. The proposed mechanisms include interference with viral envelope integrity and inhibition of viral DNA synthesis. For example, a study published in Phytotherapy Research (2007) reported that eugenol could reduce HSV-1 replication in cell cultures. Another study from the early 1990s in Antiviral Research found similar inhibitory effects on HSV-1 and HSV-2.

However, these promising laboratory findings have not yet translated into robust clinical evidence. There are currently no high-quality human trials or established topical or oral eugenol preparations approved for the treatment of herpes in medical practice. Most of the available evidence is limited to preclinical research, with no clear guidance on optimal dosing, safety, or efficacy in humans. Therefore, while there is some scientific rationale based on laboratory research, the overall evidence is limited, and eugenol cannot be recommended as a primary or proven therapy for herpes infections at this time.

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Products containing eugenol

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