Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-lysine is an essential amino acid that has been investigated as a potential supportive therapy for herpes simplex virus (HSV) infections, particularly cold sores (HSV-1). The rationale for its use is based on the relationship between lysine and another amino acid, arginine. HSV replication depends on arginine, and laboratory studies suggest that increasing lysine intake may reduce arginine availability, potentially inhibiting HSV replication.

Several small clinical trials and case reports from the 1970s through the 1990s examined the effect of L-lysine supplementation on the frequency and severity of herpes outbreaks. Some of these studies reported a reduction in outbreak frequency and symptom severity, while others found no significant benefit compared to placebo. Meta-analyses and systematic reviews conclude that the evidence is inconsistent and limited by methodological shortcomings, such as small sample sizes and variation in dosage and study design. No major guideline currently recommends L-lysine as a standard treatment for herpes, but it remains a popular over-the-counter supplement for this purpose.

In summary, the use of L-lysine for herpes is supported by a plausible biochemical mechanism and some clinical evidence, but robust, high-quality studies are lacking. The overall evidence base is weak to moderate (rated 2/5), and while some people report benefit, its effectiveness is not conclusively established.

More about l-lysine
More about Herpes

Other ingredients used for Herpes

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