Evidence supporting the use of: Lysine
For the health condition: Herpes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lysine is an essential amino acid that has been studied for its potential to reduce the recurrence and severity of herpes simplex virus (HSV) infections, particularly oral herpes (cold sores). The scientific rationale hinges on the interplay between lysine and another amino acid, arginine. HSV requires arginine for replication, and lysine is thought to competitively inhibit arginine uptake in cells. By increasing lysine intake (through supplementation or diet), arginine availability is reduced, potentially impairing viral replication.

Several clinical studies, mostly small or of moderate quality, have evaluated lysine supplementation for HSV. Some double-blind, placebo-controlled trials have reported that daily lysine (typically 1,000-3,000 mg) may reduce the frequency, duration, or severity of outbreaks. For example, a 1987 study in Dermatologica found that lysine reduced outbreak frequency and improved healing time. However, other studies have found no significant benefit, and systematic reviews, such as one published in the Journal of Antimicrobial Chemotherapy in 2005, highlight inconsistent results and methodological limitations.

Overall, there is modest scientific evidence supporting lysine’s use in reducing HSV recurrence, but the results are mixed and not universally accepted. Most guidelines recognize lysine as possibly helpful but not a primary or sole therapy. It is generally considered safe at recommended doses. More rigorous, well-powered clinical trials are needed for definitive conclusions.

More about Lysine
More about Herpes

Other health conditions supported by Lysine

Cold Sores
Herpes

Products containing Lysine

We currently have no products on Vitabase that contain this ingredient.