Neoandrographolide is a diterpenoid compound derived from Andrographis paniculata, a medicinal plant traditionally used in Asia for various ailments. In terms of supporting or treating herpes (specifically herpes simplex virus, HSV), there is some preliminary scientific evidence suggesting antiviral activity. In vitro studies have demonstrated that extracts of Andrographis paniculata, including neoandrographolide, can inhibit replication of HSV-1 in cell cultures. One study (Coon & Ernst, 2004) reviewed several antiviral effects and highlighted some activity against herpes viruses, though the main active compound discussed was andrographolide, with neoandrographolide being less extensively studied. Additional research (Wiart, 2006) mentions that neoandrographolide demonstrates in vitro antiviral properties, but direct clinical evidence in humans is lacking. There are no large-scale clinical trials or robust in vivo studies confirming its effectiveness or safety specifically for herpes infections. Thus, while there is a scientific rationale based on laboratory studies, the strength of evidence is limited and does not yet support clinical use. The current rating reflects the preliminary nature of the research and the need for further studies to establish efficacy and safety for herpes management.