Rue (Ruta graveolens) has a long history of use in traditional medicine, particularly in Mediterranean and Middle Eastern herbal practices. Traditionally, rue has been employed for various ailments, including as an antimicrobial and antiviral agent, which explains its occasional use in folk remedies for viral infections such as herpes. This use is largely based on the plant’s reputation for general “cleansing” or “purifying” properties, as well as its role in treating skin conditions.

Scientifically, however, there is very limited evidence to support the efficacy of rue against herpes simplex virus (HSV). In vitro studies have shown that some extracts of rue possess mild antiviral activity, but these effects are not specific to herpes, and no rigorous clinical trials have demonstrated effectiveness in humans for this condition. Most references to rue’s use for herpes are found in ethnobotanical surveys or herbal compendiums rather than peer-reviewed pharmacological research.

In summary, rue’s use for herpes is rooted in traditional medicine rather than scientific validation. The supporting evidence is weak (rated as 1 out of 5), based primarily on historical or anecdotal accounts rather than controlled studies or clinical data.