Evidence supporting the use of: 27-deoxyactein
For the health condition: Hot Flashes

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

27-Deoxyactein is a triterpene glycoside found in the roots of Actaea racemosa (commonly known as black cohosh), a plant traditionally used in Native American and later European herbal medicine for the relief of menopausal symptoms, including hot flashes. The use of black cohosh for this purpose dates back centuries, with historical records documenting its application for alleviating discomfort during menopause and menstruation. While 27-deoxyactein is one of the major constituents of black cohosh, the mechanism by which it or the whole extract might relieve hot flashes is not fully understood. Some hypotheses suggest possible serotonergic or estrogenic activity, but direct receptor binding studies have produced inconclusive results, and 27-deoxyactein itself has not been shown to have strong estrogenic effects.

Scientific studies on black cohosh extracts as a whole have produced mixed results, with some clinical trials showing modest improvements in hot flashes, while others show no significant effect compared to placebo. Importantly, few studies have isolated 27-deoxyactein as the active constituent, and most research focuses on the whole extract or related compounds. Thus, while black cohosh is traditionally used for hot flashes and contains 27-deoxyactein, robust scientific validation for the isolated compound’s efficacy is lacking. The evidence supporting its use is therefore largely traditional, with limited scientific corroboration.

More about 27-deoxyactein
More about Hot Flashes

Other health conditions supported by 27-deoxyactein

Hot Flashes
Menopause
PMS (general)
PMS Type P

Products containing 27-deoxyactein

We currently have no products on Vitabase that contain this ingredient.