Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Genistein is a phytoestrogen, a plant-derived compound with estrogen-like activity, found primarily in soybeans and soy products. Its use for hot flashes, particularly in menopausal women, is supported by a moderate body of scientific evidence. Hot flashes are a common symptom during menopause, often caused by decreased estrogen levels. Because genistein can bind to estrogen receptors, it is hypothesized to help alleviate these symptoms by partially compensating for the body's reduced estrogen production.

Several clinical trials and meta-analyses have investigated the effects of genistein and soy isoflavones on the frequency and severity of hot flashes. For example, a 2012 systematic review in Menopause found that genistein supplementation resulted in a significant reduction in the frequency of hot flashes compared to placebo. Similarly, a 2016 meta-analysis in Climacteric reported that higher doses of genistein were associated with greater improvements in vasomotor symptoms. However, not all studies have shown consistent results, and the magnitude of benefit appears to be modest. The safety profile is generally favorable, but long-term effects are still being studied.

In summary, the use of genistein for hot flashes is primarily supported by scientific evidence, though the effect size is moderate and some uncertainty remains. It is often considered an alternative for women who do not wish to use hormone replacement therapy or have contraindications to it.

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