Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Genistin is an isoflavone glycoside primarily found in soybeans and other legumes. It is a precursor to genistein, a well-studied phytoestrogen. The rationale for using genistin to support or treat hot flashes, particularly in menopausal women, is based on its estrogenic activity. Phytoestrogens can bind to estrogen receptors and exert weak estrogen-like effects, which may help mitigate the estrogen deficiency that underlies hot flashes during menopause. Several clinical trials and meta-analyses have investigated soy isoflavones (including genistin) for this purpose. While some studies report a modest reduction in frequency and severity of hot flashes, the effects are generally considered mild and variable between individuals. Systematic reviews (e.g., by the Cochrane Collaboration) note significant heterogeneity in study design and outcomes, with some studies showing benefit and others showing little to no effect. Overall, the evidence suggests that soy isoflavones may offer a small but statistically significant improvement in hot flash symptoms compared to placebo, but the clinical relevance is debated. The mechanism is thought to involve partial agonism of estrogen receptors, particularly ER-beta, which is more prevalent in certain tissues. In summary, while there is some scientific evidence supporting the use of genistin-containing soy isoflavones for hot flashes, the benefit is modest and not universally observed, justifying a moderate evidence rating.

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