Evidence supporting the use of: Isoflavones (mixed)
For the health condition: Hot Flashes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isoflavones, particularly those derived from soy, are commonly used to support or treat hot flashes—a frequent symptom of menopause. The scientific rationale is based on their structural similarity to estrogen, which allows them to exert weak estrogenic effects in the body by binding to estrogen receptors. Several randomized controlled trials (RCTs) and systematic reviews have examined the efficacy of isoflavones for hot flashes. While some studies suggest a modest reduction in the frequency and severity of hot flashes compared to placebo, the results are inconsistent, and not all trials demonstrate significant benefit. Meta-analyses generally conclude that isoflavones may offer a small but statistically significant improvement in hot flash symptoms, though the clinical relevance is debated.

Major guidelines, such as those from The North American Menopause Society, note that isoflavone supplements may be considered by women seeking non-hormonal management of hot flashes, particularly those who cannot use hormone therapy. However, they also emphasize the modest effect size and variability in individual response. Safety profiles are generally favorable for short-term use. In summary, the use of mixed isoflavones for hot flashes is supported by moderate-quality scientific evidence suggesting a small benefit, though not all women will experience meaningful relief.

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