Evidence supporting the use of: Soy isoflavones
For the health condition: Hot Flashes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Soy isoflavones are plant-derived compounds classified as phytoestrogens, which means they have a chemical structure similar to human estrogen and can weakly bind to estrogen receptors in the body. Their use to support or treat hot flashes, particularly in menopausal women, is primarily justified by scientific evidence, though the overall strength of the evidence is moderate (rated 3/5).

Numerous clinical trials have investigated the efficacy of soy isoflavones for reducing the frequency and severity of hot flashes. Some randomized controlled trials have shown that women taking soy isoflavone supplements experience a modest reduction in hot flash symptoms compared to placebo. The proposed mechanism is that isoflavones, such as genistein and daidzein, exert mild estrogenic effects, which may compensate for the body's declining estrogen levels during menopause.

However, results across studies have been mixed. Several meta-analyses, including a 2021 Cochrane review, concluded that soy isoflavones provide a small, statistically significant benefit for hot flashes, but the effect size is generally less than that of hormone replacement therapy. Furthermore, individual responses may vary, possibly due to genetic differences in isoflavone metabolism.

In summary, the use of soy isoflavones for hot flashes is supported by moderate scientific evidence, especially for women seeking non-hormonal options. It is not solely based on traditional use, as scientific research underpins its application for this condition.

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