Evidence supporting the use of: Soybean
For the health condition: Hot Flashes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Soybean is used to support or treat hot flashes primarily due to its content of isoflavones, which are phytoestrogens (plant-derived compounds with estrogen-like activity). Scientific interest in soy for menopausal symptoms, such as hot flashes, stems from epidemiological observations: Asian women, who traditionally consume more soy, report fewer and less severe hot flashes than women in Western countries. This observation led to research into whether soy isoflavones could help reduce hot flashes in menopausal women.

Clinical studies have produced mixed results. Some randomized controlled trials (RCTs) and meta-analyses suggest that soy isoflavone supplementation results in a modest reduction in frequency and severity of hot flashes compared to placebo, especially in women who experience at least four hot flashes per day. However, other studies find minimal or no benefit, and the effect is generally smaller than that seen with hormone replacement therapy (HRT).

The proposed mechanism is that soy isoflavones bind to estrogen receptors, particularly the beta subtype, which may help compensate for the decrease in estrogen that leads to hot flashes. Safety profiles for soy isoflavones are generally favorable for short-term use. While soy has a historical place in food traditions, its specific use for hot flashes is based on modern scientific research rather than traditional herbal medicine.

In summary, scientific evidence supports the use of soy for hot flashes to a moderate degree, but results are inconsistent and the benefit is generally modest.

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