Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha lipoic acid (ALA) is a naturally occurring antioxidant that has been explored for its potential benefits in cardiovascular health, including hypertension (high blood pressure). The rationale behind its use centers primarily on its antioxidant and anti-inflammatory properties, which may improve endothelial function—a key factor in regulating blood pressure. Several animal studies and small-scale human clinical trials have investigated the effects of ALA on blood pressure. Some evidence suggests that ALA supplementation can lead to modest reductions in both systolic and diastolic blood pressure, particularly in individuals with metabolic syndrome, diabetes, or obesity. Proposed mechanisms include the enhancement of nitric oxide bioavailability, reduction of oxidative stress, and improvement in insulin sensitivity—all of which can positively impact vascular health. However, the evidence remains limited and inconsistent. Most studies are short-term, involve small sample sizes, or combine ALA with other ingredients (such as in combination with acetyl-L-carnitine or as part of a multinutrient intervention), making it difficult to isolate the specific effects of ALA. Major health authorities and clinical guidelines do not currently endorse alpha lipoic acid as a primary or adjunctive treatment for hypertension. In summary, while there is some scientific investigation into ALA for hypertension, the current level of evidence is weak to moderate (rated 2/5). Larger, high-quality randomized controlled trials are needed before its use for hypertension management can be recommended.

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Other health conditions supported by alpha lipoic acid

Products containing alpha lipoic acid

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