Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ashitaba (Angelica keiskei) has a history of use in traditional Japanese and East Asian herbal medicine, primarily for promoting general health and longevity. In recent years, there has been growing scientific interest in ashitaba due to its unique phytochemical profile, particularly its chalcone compounds such as 4-hydroxyderricin and xanthoangelol. Some animal studies and in vitro experiments have suggested that ashitaba extracts may exert antihypertensive effects through several mechanisms, including antioxidant activity, inhibition of angiotensin-converting enzyme (ACE), and improvement of endothelial function. For example, a study published in the journal Phytotherapy Research (2017) demonstrated that ashitaba chalcones could lower blood pressure in hypertensive rat models, possibly by enhancing nitric oxide bioavailability and reducing oxidative stress.

However, human clinical evidence supporting ashitaba's efficacy for hypertension is limited. Most studies to date have been preclinical, and while the results are promising, they do not provide conclusive evidence for its use as a therapeutic agent in humans. Further research, including well-designed clinical trials, is required to clarify its potential benefits and safety profile for managing hypertension. Thus, while there is scientific rationale and preliminary evidence, the overall level of scientific validation is still low to moderate.

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