Evidence supporting the use of: Citrulline
For the health condition: Hypertension
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
L-citrulline is a non-essential amino acid that serves as a precursor to L-arginine, which is then converted to nitric oxide (NO) in the body. Nitric oxide is a vasodilator, meaning it helps relax and widen blood vessels, which can lower blood pressure. Several small clinical studies and experimental research have investigated the effect of citrulline supplementation on blood pressure, particularly in individuals with prehypertension or mild hypertension.
A meta-analysis published in 2018 in the journal Current Hypertension Reports concluded that L-citrulline supplementation can modestly reduce systolic and diastolic blood pressure, especially in populations with elevated baseline blood pressure. The reviewed studies generally used doses between 3 to 6 grams per day, and most reported only mild reductions (typically 4-7 mmHg in systolic blood pressure). The evidence base is limited by small sample sizes, short intervention durations, and some heterogeneity in results. There is stronger evidence for blood pressure reduction in specific contexts, such as in patients with endothelial dysfunction or those with higher baseline blood pressure.
Overall, there is modest scientific evidence that citrulline may help support blood pressure reduction, but it is not robust or definitive enough to recommend as a primary treatment for hypertension. Larger, longer-term trials are needed to confirm its efficacy and safety. Citrulline is not a traditional remedy for hypertension, and its use is based on modern scientific investigation rather than historical practice.
Other ingredients used for Hypertension
acai berryalfalfa
algal oil
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
banaba
barley
beet
berberine
bergamot
berry flavor
beta caryophyllene
Beta-Glucan
bilberry
black cumin
black currant
black garlic
radish
sesame
black tea
blackberry
blueberry
bonito peptide
broccoli
rice
brussel sprouts
bupleurum falcatum
calcium
canola oil
cat's claw
catechins
caterpillar mushroom
catjang cowpea
cauliflower
celery
cherry
chia seed
Chinese salvia root
chlorella
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
coleus forskohlii
collard
cucumber
daidzin
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
melon
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flaxseed
forskohlii root
fruit and vegetable blend (proprietary)
gooseberry
gotu kola
grape
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
jujube
kale
kudzu
l-arginine
l-citrulline
l-taurine
lactium casein decapeptide
lactobacillus gasseri
lactobacillus helveticus
lentinula edodes mycelia
linoleic acid (LA)
luteolin
lycopene
mackerel
magnesium
maitake mushroom
mango
marine lipid
matcha
melatonin
moringa
motherwort
naringin
nattokinase
nettle
oat
okra
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
ophiopogon root
orange
oyster mushroom
pantethine
perilla
pine bark
plum fruit
pomegranate
pomelo
potassium
prebiotic blend (proprietary)
psyllium
quail egg
quercetin
quinoa
red yeast rice
redcurrant
rehmannia glutinosa
reishi mushroom
resveratrol
rutin
rye
safflower oil
saffron
sardines
shiitake mushroom
black ginger
soybean
spinach
spirulina
stevia
strawberry
tocotrienols
tomato
almond fruit
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin C
vitamin D
vitamin D3
seaweed
watermelon
mulberry
jiaogulan
capsicum
inula racemosa
tinospora cordifolia
blackboard tree
lingzhi
morus
sunflower
ferulic acid
chrysanthemum
cistanche
dioscorea
eucommia
ganoderma
lotus seed
purslane
coix
noni
goji berry
amaranth
millet seed
algae
kidney beans
cocoa
chickpea protein
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
soursop
Arugula
Arjuna
Apigenin
Aronia melanocarpa
Allicin
Auricularia
Autumn Olive
Avocado
Ascophyllum nodosum
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Adzuki bean
Ampelopsin
Algal protein
Arjunic Acid
Alliin
anthocyanosides
Alisma
Argan nut oil
Arginine silicate
Arjunolic acid
Astragalin
Black Seed
Broussonetia
Brutieridin
Breadnut
Brown Algae
Brassica
Bayleaf
Bok Choy
Baicalein
Bael
Betanin
Bauhinia
Brazil nut
Barbasco
Bombax
Borassus aethiopum
Blue-Green Alage
banana
Baicalin
Buckwheat
Bassia scoparia
Bignay
Bottle gourd
Chia seed
Caffeic Acid
Camellia sinensis
Chinese Silkvine
Cowpea
California chia
Cyanobacteria
Catalpol
Cod Liver Oil
Chive
chlorogenic acid
Chinese Fleeceflower
Cantaloupe
Chlorophytum
Cruciferous
Cyclanthera pedata
Capers
Coconut Water
Chocolate
Chinese Ligustrum berry
C-Phycocyanin
Cha de bugre
Cherimoya
Crocetin
Carambola
Cassava
Clerodendrum indicum
Currant
Danshen
Daidzein
Dragon Fruit
Date
epicatechin
Eriocitrin
eggplant
Emblicanin
Eicosapentaenoic Acid
Eucommia ulmoides
Ecklonia
Fig
Fiber
Flavonones
Flammulina velutipes
Glycine
Isoflavones
Lotus
Milk Protein
Mistletoe
Prickly Pear Cactus
Quinoa Protein
Soy Protein
Sandalwood
Squash
walnut
Zucchini
Other health conditions supported by Citrulline
AnginaAthletic and Exercise Aids
Cardiovascular Disease
Circulation (poor)
Congestive Heart Failure
Erectile Dysfunction
Exercise
Fatigue
Hypertension
Sex Drive (low)