Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrus bioflavonoids are plant compounds found in citrus fruits such as oranges, lemons, and grapefruits. They are sometimes promoted for cardiovascular health, including the management of hypertension (high blood pressure). The rationale is mainly based on their antioxidant, anti-inflammatory, and vasodilatory effects, which could theoretically improve endothelial function and vascular health.

Some preclinical and limited human studies suggest that certain bioflavonoids—such as hesperidin, naringin, and diosmin—may help lower blood pressure or improve vascular tone. For example, a few small randomized controlled trials (RCTs) and observational studies have reported modest reductions in blood pressure or improvements in arterial stiffness after supplementation with citrus flavonoids. Proposed mechanisms include enhanced nitric oxide production and reduced oxidative stress in the vascular endothelium.

However, the overall quality and quantity of human evidence are limited. Most clinical trials to date have been small, short-term, or used mixed flavonoid preparations, making it difficult to attribute effects specifically to citrus bioflavonoids or to generalize results. Major clinical guidelines for hypertension do not currently recommend citrus bioflavonoid supplements as a standard treatment. Thus, while there is some scientific rationale and preliminary evidence, robust, large-scale clinical trials are lacking, and the strength of evidence supporting their use for hypertension is currently low.

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Other ingredients used for Hypertension

Other health conditions supported by citrus bioflavonoids

Products containing citrus bioflavonoids

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Pure Encapsulations Hair/Skin/Nails Ultra
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Metagenics Immune Defense Pack
Integrative Therapeutics K-PAX MitoNutrients
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Metagenics Multigenics®
Metagenics Multigenics Intensive Care
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Metagenics Multigenics without Iron
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Integrative Therapeutics Nutrivitamin No-Iron
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Designs For Health Primal Multi™
Pure Encapsulations PurePals
Pure Encapsulations PurePals with Iron
Vitabase Quercetin Plus
Designs For Health Stellar C™
Metagenics Ultra Potent-C 1000
Metagenics Ultra Potent-C 500
Metagenics Ultra Potent-C Chewable
Metagenics Ultra Potent-C Powder
Douglas Laboratories Ultra Preventive ® Kids Grape Flavor
Douglas Laboratories Ultra Preventive ® Kids Orange Flavor
Thorne Vitamin C With Flavonoids
Integrative Therapeutics Vitamin C with Quercetin
Metagenics Wellness Essentials Active Daily Packs