Relationship: Hypertension and EPA (eicosapentaenoic acid)

Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Hypertension

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Source of validity: Scientific
Rating (out of 5): 3

Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid found primarily in fatty fish and fish oil supplements, has been studied for its potential benefits in cardiovascular health, including the management of hypertension. Scientific evidence suggests that EPA, often in combination with docosahexaenoic acid (DHA), can have modest blood pressure-lowering effects. Meta-analyses of randomized controlled trials have shown that supplementation with omega-3 fatty acids can reduce both systolic and diastolic blood pressure, particularly in individuals with untreated hypertension or those with higher baseline blood pressure. The likely mechanisms include EPA’s ability to improve endothelial function, reduce inflammation, decrease vascular resistance, and modulate the production of vasodilatory eicosanoids.

However, the magnitude of the effect is generally small—on the order of 2–4 mmHg for systolic blood pressure. The American Heart Association recognizes omega-3 fatty acids as part of a heart-healthy diet, but they do not recommend omega-3 supplements as a primary therapy for hypertension due to these modest effects. Most clinical trials use combined EPA and DHA, making it difficult to isolate the effect of EPA alone. Nonetheless, pure EPA formulations (such as icosapent ethyl) have demonstrated cardiovascular benefits in large clinical trials, although their specific effects on blood pressure are less clear.

In summary, there is scientific evidence supporting the use of EPA (and omega-3s in general) for mild blood pressure reduction, but the effect size is modest and supplementation should not replace standard antihypertensive therapy.

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Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Hypertension

Table of Contents

Synopsis

Other ingredients used for Hypertension

Other health conditions supported by EPA (eicosapentaenoic acid)

Products containing EPA (eicosapentaenoic acid)

Health Concerns

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Evidence supporting the use of: EPA (eicosapentaenoic acid)For the health condition: Hypertension

Table of Contents

Synopsis

Other ingredients used for Hypertension

Other health conditions supported by EPA (eicosapentaenoic acid)

Products containing EPA (eicosapentaenoic acid)

Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Hypertension