Evidence supporting the use of: Hesperitin
For the health condition: Hypertension

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperetin is a flavonoid compound found predominantly in citrus fruits and is the aglycone of hesperidin. There is some scientific evidence suggesting that hesperetin may have beneficial effects on blood pressure regulation, primarily based on preclinical studies. Animal studies have indicated that hesperetin exerts vasodilatory effects, improves endothelial function, and may reduce oxidative stress and inflammation, all of which are mechanisms implicated in hypertension. A few small-scale human studies and clinical trials with related compounds (like hesperidin) suggest potential antihypertensive effects, but the direct clinical evidence for hesperetin itself is limited. Systematic reviews and meta-analyses of flavonoid supplementation, which sometimes include hesperetin, have shown modest reductions in blood pressure, though the effects appear to be more pronounced in preclinical models than in humans.

Despite these promising findings, hesperetin is not widely recognized as a primary treatment for hypertension in clinical practice, and no major hypertension guidelines recommend its use. Most available evidence is preliminary, with a lack of large, well-controlled human trials specifically addressing hesperetin’s effect on hypertension. Therefore, while the biological plausibility exists and preclinical data are encouraging, the current level of scientific validation is modest. More rigorous clinical research is needed before hesperetin can be confidently recommended for hypertension management.

More about Hesperitin
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Other ingredients used for Hypertension

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alfalfa
algal oil
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
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barley
beet
berberine
bergamot
berry flavor
beta caryophyllene
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bilberry
black cumin
black currant
black garlic
radish
sesame
black tea
blackberry
blueberry
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broccoli
rice
brussel sprouts
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calcium
canola oil
cat's claw
catechins
caterpillar mushroom
catjang cowpea
cauliflower
celery
cherry
chia seed
Chinese salvia root
chlorella
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
coleus forskohlii
collard
cucumber
daidzin
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
melon
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flaxseed
forskohlii root
fruit and vegetable blend (proprietary)
gooseberry
gotu kola
grape
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
jujube
kale
kudzu
l-arginine
l-citrulline
l-taurine
lactium casein decapeptide
lactobacillus gasseri
lactobacillus helveticus
lentinula edodes mycelia
linoleic acid (LA)
luteolin
lycopene
mackerel
magnesium
maitake mushroom
mango
marine lipid
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melatonin
moringa
motherwort
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nattokinase
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chlorogenic acid
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Products containing Hesperitin

We currently have no products on Vitabase that contain this ingredient.