Evidence supporting the use of: Hydroxycinnamic acid
For the health condition: Hypertension
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Hydroxycinnamic acids are a class of polyphenolic compounds found abundantly in foods such as coffee, fruits, whole grains, and vegetables. The most well-studied hydroxycinnamic acids include caffeic acid, ferulic acid, and p-coumaric acid. Scientific interest in these compounds stems from their antioxidant and vasodilatory properties, which have been hypothesized to benefit cardiovascular health, including hypertension.
Some animal and limited human studies suggest that hydroxycinnamic acids may contribute to lowering blood pressure. For instance, research on chlorogenic acid (a major hydroxycinnamic acid in coffee) has demonstrated moderate reductions in systolic and diastolic blood pressure in hypertensive subjects, possibly through improvements in endothelial function and nitric oxide-mediated vasodilation. However, these effects have not been universally observed, and the impact is generally modest. Most clinical studies involve extracts or foods rich in hydroxycinnamic acids rather than isolated compounds, making it difficult to attribute effects solely to hydroxycinnamic acids.
Overall, there is some scientific evidence supporting a potential benefit of hydroxycinnamic acids for hypertension, but the evidence is not robust, and the effect size appears small. Major clinical guidelines do not recognize hydroxycinnamic acid as a primary or standalone treatment for hypertension. More high-quality, targeted clinical trials are needed to clarify efficacy and mechanisms.
Other ingredients used for Hypertension
acai berryalfalfa
algal oil
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
banaba
barley
beet
berberine
bergamot
berry flavor
beta caryophyllene
Beta-Glucan
bilberry
black cumin
black currant
black garlic
radish
sesame
black tea
blackberry
blueberry
bonito peptide
broccoli
rice
brussel sprouts
bupleurum falcatum
calcium
canola oil
cat's claw
catechins
caterpillar mushroom
catjang cowpea
cauliflower
celery
cherry
chia seed
Chinese salvia root
chlorella
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
coleus forskohlii
collard
cucumber
daidzin
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
melon
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flaxseed
forskohlii root
fruit and vegetable blend (proprietary)
gooseberry
gotu kola
grape
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
jujube
kale
kudzu
l-arginine
l-citrulline
l-taurine
lactium casein decapeptide
lactobacillus gasseri
lactobacillus helveticus
lentinula edodes mycelia
linoleic acid (LA)
luteolin
lycopene
mackerel
magnesium
maitake mushroom
mango
marine lipid
matcha
melatonin
moringa
motherwort
naringin
nattokinase
nettle
oat
okra
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
ophiopogon root
orange
oyster mushroom
pantethine
perilla
pine bark
plum fruit
pomegranate
pomelo
potassium
prebiotic blend (proprietary)
psyllium
quail egg
quercetin
quinoa
red yeast rice
redcurrant
rehmannia glutinosa
reishi mushroom
resveratrol
rutin
rye
safflower oil
saffron
sardines
shiitake mushroom
black ginger
soybean
spinach
spirulina
stevia
strawberry
tocotrienols
tomato
almond fruit
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin C
vitamin D
vitamin D3
seaweed
watermelon
mulberry
jiaogulan
capsicum
inula racemosa
tinospora cordifolia
blackboard tree
lingzhi
morus
sunflower
ferulic acid
chrysanthemum
cistanche
dioscorea
eucommia
ganoderma
lotus seed
purslane
coix
noni
goji berry
amaranth
millet seed
algae
kidney beans
cocoa
chickpea protein
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
soursop
Arugula
Arjuna
Apigenin
Aronia melanocarpa
Allicin
Auricularia
Autumn Olive
Avocado
Ascophyllum nodosum
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Adzuki bean
Ampelopsin
Algal protein
Arjunic Acid
Alliin
anthocyanosides
Alisma
Argan nut oil
Arginine silicate
Arjunolic acid
Astragalin
Black Seed
Broussonetia
Brutieridin
Breadnut
Brown Algae
Brassica
Bayleaf
Bok Choy
Baicalein
Bael
Betanin
Bauhinia
Brazil nut
Barbasco
Bombax
Borassus aethiopum
Blue-Green Alage
banana
Baicalin
Buckwheat
Bassia scoparia
Bignay
Bottle gourd
Chia seed
Caffeic Acid
Camellia sinensis
Chinese Silkvine
Cowpea
California chia
Cyanobacteria
Catalpol
Cod Liver Oil
Chive
chlorogenic acid
Chinese Fleeceflower
Cantaloupe
Chlorophytum
Cruciferous
Cyclanthera pedata
Capers
Coconut Water
Chocolate
Chinese Ligustrum berry
C-Phycocyanin
Cha de bugre
Cherimoya
Crocetin
Carambola
Cassava
Clerodendrum indicum
Currant
Danshen
Daidzein
Dragon Fruit
Date
epicatechin
Eriocitrin
eggplant
Emblicanin
Eicosapentaenoic Acid
Eucommia ulmoides
Ecklonia
Fig
Fiber
Flavonones
Flammulina velutipes
Glycine
Isoflavones
Lotus
Milk Protein
Mistletoe
Prickly Pear Cactus
Quinoa Protein
Soy Protein
Sandalwood
Squash
walnut
Zucchini
Other health conditions supported by Hydroxycinnamic acid
Cancer (prevention)Cardiovascular Disease
Cholesterol (high)
Diabetes
Digestion (poor)
Fatty Liver Disease
Free Radical Damage
Hypertension
Inflammation
Triglycerides (high)
Ulcers
Wounds and Sores