Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Jiaogulan (Gynostemma pentaphyllum) is traditionally used in East Asian herbal medicine for its adaptogenic and health-promoting properties, including cardiovascular support. In recent decades, scientific interest has grown regarding its potential benefit in managing hypertension (high blood pressure). Several animal studies and small-scale human clinical trials have investigated jiaogulan’s effects on blood pressure. The key active constituents, known as gypenosides, are believed to exert vasodilatory effects (widening of blood vessels) and improve endothelial function, both of which can help lower blood pressure. Some research suggests these compounds may also modulate the renin-angiotensin system and have antioxidant properties that protect vascular health.

A notable double-blind, placebo-controlled human study published in 2012 found that jiaogulan extract, taken for 12 weeks, resulted in a modest but statistically significant reduction in both systolic and diastolic blood pressure among participants with mild hypertension. However, these studies often involve small sample sizes and short durations, and the exact mechanisms of action remain under investigation. While the evidence is promising, it is not yet robust enough to recommend jiaogulan as a replacement for standard antihypertensive medications. Instead, it may have a role as an adjunctive or complementary therapy. As always, individuals should consult with healthcare professionals before starting any new supplement, especially if they have cardiovascular conditions or are taking medication for hypertension.

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