Evidence supporting the use of: Ligustilide
For the health condition: Hypertension

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ligustilide is a major bioactive component found in certain traditional Chinese medicinal herbs, most notably Angelica sinensis (Dong Quai) and Ligusticum chuanxiong (Chuanxiong). Its use for supporting or treating hypertension (high blood pressure) originates primarily from traditional medicine practices. In Chinese medicine, these herbs have been used in formulas aimed at "invigorating blood circulation" and "dispelling wind," which are sometimes interpreted as supportive for cardiovascular health, including hypertension.

There is some emerging preclinical scientific evidence (mainly from animal studies and in vitro research) suggesting that ligustilide may exert vasodilatory effects, reduce vascular resistance, and have anti-inflammatory properties. These mechanisms could, in theory, support blood pressure reduction. However, robust clinical data in humans are lacking. Most scientific literature to date focuses on potential mechanisms but does not provide direct evidence for efficacy in treating hypertension in humans. As such, the evidence is rated as 2, reflecting weak scientific support and primary justification from traditional use. No major guidelines or clinical trials currently endorse ligustilide for hypertension management.

In summary, ligustilide is used for hypertension based on traditional practices, with only limited and preliminary scientific evidence to support this use. More rigorous clinical studies are needed to confirm its efficacy and safety for this indication.

More about Ligustilide
More about Hypertension

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Products containing Ligustilide

We currently have no products on Vitabase that contain this ingredient.