Plukenetia volubilis (commonly known as Sacha Inchi) has been investigated in several preclinical and a few clinical studies for its potential effects on hypertension. The seeds of Plukenetia volubilis are rich in omega-3 and omega-6 fatty acids, which have been associated with cardiovascular health and blood pressure regulation in the broader scientific literature. Animal studies have indicated that extracts or oils from Sacha Inchi may exert antihypertensive activity, likely mediated through mechanisms such as vasodilation, reduction of oxidative stress, and anti-inflammatory effects. For example, a 2016 animal study published in the Journal of Medicinal Food showed that Sacha Inchi oil supplementation reduced blood pressure in hypertensive rats.

Human evidence, however, remains limited. A few small-scale clinical trials with Sacha Inchi oil supplementation have reported improvements in lipid profiles and some markers of cardiovascular risk, but effects specifically on blood pressure are either modest or not the primary outcome measured. No large, well-controlled clinical trials have definitively established the efficacy of Plukenetia volubilis in the management of hypertension. Therefore, while there is some scientific rationale and preliminary evidence, the overall strength of evidence supporting its use for hypertension is still considered low (rated 2 out of 5).