Evidence supporting the use of: Triterpene Saponin
For the health condition: Hypertension

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Triterpene saponins are a diverse group of naturally occurring compounds found in various medicinal plants, such as ginseng (Panax ginseng), licorice (Glycyrrhiza glabra), and others. There is some scientific evidence supporting the potential antihypertensive effects of triterpene saponins, though the quality and quantity of human studies are limited. Preclinical research, including in vitro and animal studies, suggests that triterpene saponins may exert blood pressure-lowering effects through several mechanisms, such as vasodilation, inhibition of angiotensin-converting enzyme (ACE) activity, improvement of endothelial function, and antioxidant activity. For instance, studies on ginsenosides (a type of triterpene saponin found in ginseng) have demonstrated reductions in blood pressure in hypertensive animal models, possibly by modulating nitric oxide production and reducing vascular resistance.

However, clinical trials in humans are sparse and often limited by small sample sizes, short durations, and variable quality. Some studies with ginseng extracts report modest reductions in blood pressure, but these findings are not consistent, and the specific contribution of triterpene saponins versus other constituents is unclear. Overall, while there is a scientific rationale and preliminary evidence for the use of triterpene saponins in managing hypertension, robust clinical data are lacking. Therefore, the evidence supporting their use in hypertension is rated as low to moderate (2 out of 5).

More about Triterpene Saponin
More about Hypertension

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Products containing Triterpene Saponin

We currently have no products on Vitabase that contain this ingredient.