Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 (cholecalciferol) has been investigated for its potential role in supporting or treating hypertension (high blood pressure), primarily due to observations that vitamin D deficiency is associated with increased cardiovascular risk and higher blood pressure. Several mechanistic hypotheses exist: vitamin D may suppress renin expression, modulate vascular smooth muscle function, and influence inflammation, all of which could affect blood pressure regulation.

However, while observational studies often find a correlation between low vitamin D levels and higher blood pressure, interventional studies and randomized controlled trials (RCTs) have not consistently demonstrated that vitamin D supplementation reduces blood pressure in the general population. A 2019 meta-analysis in Hypertension reviewed data from over 80,000 participants and found that vitamin D supplementation had a minimal effect on systolic and diastolic blood pressure, with most studies showing no significant clinical benefit. Some subgroups, such as those with severe vitamin D deficiency or specific genetic backgrounds, may experience modest reductions in blood pressure, but these findings are not robust or broadly generalizable.

Therefore, while there is scientific interest and some mechanistic rationale for using vitamin D3 in hypertension, the overall evidence supporting its effectiveness is weak (rating: 2/5). Vitamin D3 should not be considered a primary treatment for hypertension, but maintaining adequate vitamin D levels is important for overall health.

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