Evidence supporting the use of: Adrenergic amines
For the health condition: Hypotension

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Adrenergic amines—such as epinephrine, norepinephrine, dopamine, and dobutamine—are widely and robustly used in modern medicine for the acute management of hypotension, particularly in critical care settings. These agents act primarily by stimulating adrenergic receptors (alpha and/or beta), leading to increased vascular tone, heart rate, and myocardial contractility. Their pharmacological effects result in rapid elevation of blood pressure, which can be life-saving for patients experiencing shock or severe hypotension due to various causes (e.g., septic shock, cardiogenic shock, anaphylaxis).

There is strong scientific evidence supporting their efficacy, underpinned by decades of clinical research, randomized controlled trials, and inclusion in major international guidelines (e.g., Surviving Sepsis Campaign, American Heart Association Advanced Cardiovascular Life Support). The choice of a specific adrenergic amine depends on the underlying etiology of hypotension and patient-specific factors. For example, norepinephrine is the first-line vasopressor in septic shock, whereas dopamine may be considered in certain cases of bradycardia with hypotension.

Thus, the use of adrenergic amines for treating hypotension is not only scientifically validated but also represents a cornerstone of evidence-based critical care. Their dosing, administration, and monitoring protocols are well established in clinical practice, reflecting a high level of confidence in their therapeutic benefit for this indication.

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