Evidence supporting the use of: Exphedrine HCl
For the health condition: Hypotension

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Ephedrine HCl is a sympathomimetic amine that has been scientifically validated for the treatment of hypotension, particularly perioperative hypotension (low blood pressure during anesthesia or surgery). Its mechanism of action involves both direct and indirect stimulation of adrenergic receptors, resulting in increased cardiac output and peripheral vascular resistance, which together elevate blood pressure. Clinical guidelines and numerous peer-reviewed studies support the use of ephedrine in acute care settings, especially when hypotension is related to spinal or epidural anesthesia. For example, the "British Journal of Anaesthesia" and "Anesthesia & Analgesia" have published multiple studies demonstrating its efficacy and safety profile compared to other vasopressors. While other agents like phenylephrine may be preferred in some scenarios due to a more predictable effect on heart rate and blood pressure, ephedrine remains a first-line or alternative agent in many anesthetic protocols. Its use outside the perioperative or acute care setting is less supported, but in controlled environments, the evidence base is robust. Therefore, the scientific validation for ephedrine HCl in the management of hypotension, particularly in acute or perioperative contexts, is strong (rated 4 out of 5).

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Products containing Exphedrine HCl

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