Convolvulus pluricaulis, commonly known as Shankhpushpi, has a long history of use in traditional Ayurvedic medicine as a tonic for the mind and nervous system. In Ayurveda, it is classified as a "Medhya Rasayana," meaning it is believed to support cognitive function, memory, and mental clarity. While the hypothalamus is not specifically identified in traditional Ayurvedic texts, Shankhpushpi is often prescribed for conditions thought to involve stress, anxiety, and neuroendocrine imbalances, which are functions in part regulated by the hypothalamus in modern physiology.

Scientific studies on Convolvulus pluricaulis are limited. Some animal studies have indicated neuroprotective, anxiolytic, and cognitive-enhancing effects, suggesting possible modulation of neurotransmitter levels and stress responses. However, direct evidence connecting Convolvulus pluricaulis to support of the hypothalamus specifically—such as modulation of hypothalamic hormones or direct action on hypothalamic function—is lacking. Most human research relates to general cognitive enhancement or anti-anxiety effects rather than targeted hypothalamic support.

In summary, the use of Convolvulus pluricaulis to support the hypothalamus is primarily justified by traditional use and general neurotonic effects described in Ayurveda, not by robust modern scientific evidence directly linking it to hypothalamic function.