Evidence supporting the use of: DHA-conjugated phosphatidylserine
For the body system: Hypothalamus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

DHA-conjugated phosphatidylserine (PS-DHA) is a specialized form of the phospholipid phosphatidylserine (PS) that is bound to docosahexaenoic acid (DHA), an omega-3 fatty acid. PS is a key component of neuronal membranes and has been investigated for its cognitive and neuroprotective benefits, with some human studies suggesting improvements in memory, attention, and stress response. DHA is also crucial for brain function and development, particularly within the hypothalamus, which regulates hormonal and metabolic processes. Research specifically examining PS-DHA conjugates is limited but growing. Animal studies and some pilot human trials indicate that PS-DHA can cross the blood-brain barrier more efficiently than PS or DHA alone, potentially enhancing membrane fluidity and supporting synaptic function in brain regions such as the hypothalamus. A few studies have shown that PS-DHA supplementation may modulate stress hormone levels (such as cortisol) and support hypothalamic-pituitary-adrenal (HPA) axis regulation, which are core hypothalamic functions. However, large-scale clinical trials directly linking PS-DHA supplementation to improved hypothalamic function in humans are lacking. In summary, while there is a plausible scientific rationale and some preliminary evidence for the use of DHA-conjugated phosphatidylserine to support hypothalamic health, robust clinical validation is currently insufficient. The evidence base is stronger for cognitive and general brain health, with hypothalamic-specific outcomes still under investigation.

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