Evidence supporting the use of: Eleutherococcus senticosus
For the body system: Hypothalamus

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Eleutherococcus senticosus, also known as Siberian ginseng, has a long history of use in traditional medicine, especially in Russia and East Asia. It is classified as an adaptogen, a substance believed to help the body resist stressors of all kinds, including physical, chemical, and biological. Traditional use has often focused on its ability to help the body adapt to stress, which is mediated in large part by the hypothalamic-pituitary-adrenal (HPA) axis, with the hypothalamus playing a central role. While traditional herbalists have associated Eleutherococcus senticosus with support for "adrenal" or "stress" function, these claims are based largely on anecdotal evidence and empirical use rather than rigorous scientific validation specifically targeting the hypothalamus.

Some studies have suggested that Eleutherococcus senticosus may modulate stress response and fatigue, but these generally assess overall HPA axis activity or nonspecific stress adaptation, not the hypothalamus in isolation. There is a lack of direct scientific evidence that it specifically supports hypothalamic function. Most support for its use in this context comes from its traditional application as an adaptogen, which, by extension, is thought to involve the hypothalamus. Therefore, the justification for using Eleutherococcus senticosus to support the hypothalamus is primarily traditional, with limited and indirect scientific support.

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