Evidence supporting the use of: Ginsenoside
For the body system: Hypothalamus

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ginsenosides, the active compounds found in ginseng (Panax species), have a long history of use in Traditional Chinese Medicine (TCM) as adaptogens, believed to help the body resist stress and restore balance. In TCM, ginseng is often prescribed to tonify "Qi" and support various bodily systems, including the hypothalamic-pituitary-adrenal (HPA) axis. While animal and in vitro studies have shown that certain ginsenosides can influence the secretion of stress hormones (such as corticotropin-releasing hormone and adrenocorticotropic hormone) and modulate HPA axis activity, direct clinical evidence in humans specifically linking ginsenosides to hypothalamus function is limited. Most human research has focused on general stress adaptation, fatigue, and immune modulation rather than direct hypothalamic support. Therefore, while the traditional use of ginsenosides for supporting systems that include the hypothalamus is well established, scientific validation specifically targeting the hypothalamus is preliminary and not robust. In summary, the use of ginsenosides for hypothalamic support is justified primarily by tradition and historical usage, with limited early-stage scientific support.

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