Evidence supporting the use of: Holy Basil Herb
For the body system: Hypothalamus

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Holy Basil (Ocimum sanctum), also known as Tulsi, has a long history of use in Ayurvedic medicine as an adaptogen—an herb believed to help the body resist physical, chemical, and biological stressors. In traditional systems, Holy Basil is considered to have a balancing effect on the mind and body, which extends to the hypothalamus as part of the body’s stress response system (the hypothalamic-pituitary-adrenal or HPA axis). The hypothalamus plays a central role in regulating stress hormones, and Holy Basil's use is historically linked to supporting mental clarity, reducing anxiety, and promoting resilience to stress.

Scientific validation for Holy Basil’s direct effect on the hypothalamus is limited. Some animal studies and preliminary human research suggest that Holy Basil may modulate stress responses, potentially impacting cortisol and other stress-related hormones regulated by the hypothalamus, but clear, high-quality clinical evidence specific to direct hypothalamic support is lacking. Most supporting evidence is extrapolated from its adaptogenic properties and traditional use rather than robust scientific trials targeting the hypothalamus specifically. Therefore, its primary justification is traditional, with modest supportive evidence.

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