Panax Notoginseng (also known as Sanqi or Tienchi ginseng) has a long history of use in traditional Chinese medicine (TCM), where it is valued for its purported abilities to invigorate blood, reduce inflammation, and support overall body balance. In TCM, the hypothalamus is not recognized as a distinct anatomical entity; instead, functions that Western medicine attributes to the hypothalamus—such as hormonal regulation, stress response, and homeostasis—are discussed more broadly within the context of balancing "Qi" and harmonizing body systems.

There is no specific historical or scientific documentation indicating that Panax Notoginseng was used explicitly to target the hypothalamus as understood in modern physiology. However, its traditional use as an adaptogen and for improving vitality and resilience may be indirectly associated with effects on the hypothalamic-pituitary-adrenal (HPA) axis, which governs stress response. Some preclinical studies suggest that Panax Notoginseng saponins can have neuroprotective and anti-stress effects, but these findings are preliminary and not directly linked to hypothalamic function in humans. Overall, the use of Panax Notoginseng for hypothalamic support is based more on traditional systems of health and generalized adaptogenic properties rather than direct scientific validation.