Evidence supporting the use of: Methylsulfonylmethane (MSM)
For the body system: Immune System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Methylsulfonylmethane (MSM) is an organosulfur compound commonly used as a dietary supplement. Its most established uses are for joint health and reducing inflammation, but there is some scientific interest in its potential to support the immune system. Several animal and in vitro studies suggest that MSM may modulate immune response by reducing oxidative stress and inflammation. For example, MSM has been shown to suppress the production of inflammatory cytokines, such as IL-6 and TNF-α, in immune cells. A limited number of human studies exist; one small randomized controlled trial found that MSM supplementation reduced markers of inflammation and may have supported immune resilience in physically active individuals under stress. However, the evidence base remains limited, and the few human studies available often have small sample sizes and short durations. While MSM is not traditionally used for immune health and is not a first-line supplement for immune support, the current scientific evidence suggests a potential mild benefit. More large-scale, rigorous human studies are needed to confirm these effects. Thus, MSM’s use for immune system support has some scientific basis, but the overall strength of the evidence is modest.

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Other body systems supported by methylsulfonylmethane (MSM)

Hair
Immune System
Muscles
Skin
Structural System
Joints