Relationship: Immune System and selenium

Evidence supporting the use of: Selenium
For the body system: Immune System

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Selenium is an essential trace mineral that plays a significant role in the immune system. Scientific evidence supports its importance, particularly due to its function as a cofactor for antioxidant enzymes such as glutathione peroxidases, which help protect immune cells from oxidative stress. Multiple studies have shown that selenium deficiency impairs immune responses, making individuals more susceptible to infections. For example, selenium-deficient individuals have demonstrated poorer responses to viral infections, and animal research indicates that deficiency can worsen the severity of some viral diseases.

Clinical studies in humans suggest that selenium supplementation may improve immune function in people with low selenium status, such as the elderly or those with certain chronic diseases. Selenium's role in promoting optimal immune function is also supported by research showing that supplementation can enhance cellular immunity, including increased proliferation of T-cells and improved activity of natural killer (NK) cells. However, evidence for selenium supplementation benefiting immune health in individuals who are not deficient is less robust.

Overall, while selenium is scientifically validated as necessary for normal immune function, the direct benefit of supplementation for immune support is most evident in those with suboptimal selenium status. Excessive intake can be toxic, so supplementation should be approached with caution and ideally guided by clinical assessment of selenium levels.

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3,3'-dihydroxy-B-carotene-4,4'-dione
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Agonandra
Agrimonia pilosa
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algal oil
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Allicin
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Allium tuberosum
Allspice
Allyl sulfide
Aloe vera
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alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
alpha-pinene
alpinia galangal
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ampelopsin
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ananain
anchovies
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anise
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anthocyanins
anthocyanosides
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apple cider vinegar
apricot
arabinogalactan
arabinoxylan
arachidonic acid
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bacillus coagulans
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bacillus subtilis
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beta-zeacarotene
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betulinic acid
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black gram
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black poplar
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black tea
black walnut
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bladderwrack
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boneset
borage
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bovine liver
bovine protein
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Brassica
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Brevibacillus
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broccoli
bromelain
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C-phycocyanin
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cactus
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caffeic Acid
cajuput
calamari oil
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cowslip
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curry leaf
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fireweed
fisetin
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fish oil
fish protein
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flat-stem milk-vetch
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flavans
flavones
flavonoids
flavonolignan
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flowering quince
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fo-ti
folate
folic acid
Fomes fomentarius
Fomitopsis pinicola
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forsythia
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frankincense
fritillaria
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fu ling
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fucosterol
fulvic acid
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fungus
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Galbanum
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Gallesia
gamma linolenic acid (GLA)
gamma tocopherol
gamma-glutamylcysteine
gamma-terpinene
ganoderma
garbanzo bean
garden cress
gardenia
Gardenia jasminoides
garlic
garlic bulb
gastrodia
Genipa americana
genipap
Gentiana macrophylla
Gentiana manshurica
Gigartina
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ginseng
Ginsenosides
Glechoma hederacea
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Glucoraphanin
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glyceryl monolaurate
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Glycosaponin
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Glycyrrhetinic acid
Glycyrrhizin
Gnaphalium
goji berry
gokhru
golden eardrops
goldenrod
goldenseal
goldthread
gooseberry
gotu kola
grapefruit
Graviola
Greek mountain tea
green banana
green bell pepper
green chiretta
green tea
green-lipped mussel
greens blend (proprietary)
Guaco
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guggul
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Hedychium spicatum
Hedyotis
Helicteres isora
Hemidesmus
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herbal blend (proprietary)
hericium mushroom
hesperetin
hesperidin
hibiscus
HMB hydroxymethylbutyrate
holarrhena antidysenterica
honey
honey loquat syrup
honeybush
honeysuckle
Honokiol
horehound
horse gram
Horsemint
horseradish
Houttuynia
Huang hua
huckleberry
Humic acid
hyacinth bean
hydroxymethylbutyrate
hydroxytyrosol
Hygrophila
Hypericum
Hyperoside
Hyphomycetes
hypsizygus marmoreus
hyssop
Ilex
Immortelle
immunoglobin G
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Indian bael
Indian coraltree
Indian fagonia
Indian frankincense
Indian gum arabic tree
Indian nightshade
Indian sarsparilla
Indian tinospora
indigo leaves
indole-3-carbinol
inula racemosa
inulin
iodine
Iporuru
iridoid glycosides
iridoids
iron
Isatis
isobutylamides
isodon excisus
isodon rubescens
Isoleucine
isomalto-oligosaccharide
isothiocyanates
Jaboticaba
Japanese kadsura
Japanese sophora
Jatamansi
Jatoba
Java brucea
Javanese Long Pepper
jiaogulan
Job\'s tears
jujube
jungli-bean
juniper berries
Kachnar
Kaempferol
Kalanchoe pinnatum
kale
Kefir
Kefiran
kidney beans
Kigelia africana
kiwi
knotgrass
knotweed
Kohlrabi
Kokilaksha
Kombucha
krill oil
kuding tea
kudzu
Kumquat
Kutkins
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-alanyl-L-glutamine
L-arginine
L-cysteine
L-glutamine
L-glutathione
L-glycine
l-isoleucine
L-leucine
L. lactis
Labisia pumila
labrador tea
lactalbumin
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus crispatus
Lactobacillus delbrueckii
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus helveticus
Lactobacillus jensenii
Lactobacillus johnsonii
Lactobacillus kefiranofaciens
Lactobacillus kefiri
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
Lactococcus lactis
Lactococcus rhamnosus
Lactoferrin
lactoglobulin
Lactoperoxidase
Laggera pterodonta
Lantana camara
Lapachol
Larch
Large-leaved linden
lauric acid
Lebbek
Ledebouriella
Legume protein
lemon
lemon balm
lemongrass
Lentil
Lentinan
Lentinula edodes mycelia
Leptadenia
Leptospermum scoparium
lichen
licorice root
lignans
Ligusticum
Ligustrum
Lilium polyphyllum
lime
Limonium sinense
limonoid
linden
Lindera
lingonberry
lingzhi
linoleic acid (LA)
lion's mane
lipids
little ironweed
Lomatium
long pepper
longan
lophatherum leaf
Lophira lanceolata
loquat
Loranthus
lotus seed
lucuma
luffa
lungwort
luteolin
lychee
Lycium
lycopene
Lycoris
lysophosphatidylcholine
lysozyme
maca
Macaranga indica
mace
Maclura tricuspidata
magnesium
magnolia
magnolol
Mahonia
maitake mushroom
malabar nut
mallow
Malva sylvestris
Manchurian thorn
manganese
mangiferin
mango
mangosteen
mangostene xanthone
mangostin
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maqui berry
marigold
Marine fat
Marine lipid
Marine protein
Marjoram
Marking Nut Tree
Marshmallow
Maslinic acid
Matapalo Tree
Matcha
Mate
Matico
Meadow sage
medium chain triglycerides (MCT)
melaleuca alternifolia
Melatonin
Melia
Mentha haplocalyx
Mesima
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Methylselenocysteine
Methylsulfonylmethane (MSM)
Mezoneuron benthamianum
Microbial enzymes (proprietary)
Microtea debilis
Milk
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millet seed
Mimosa
Mineral ascorbate
Ming Dang Shen
Mint
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mixed carotenoids
Molasses
Momordica
Momordicosides
Monardella odoratissima
Monolaurin
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Monounsaturated fat
Morinda
Moringa
Mormon Tea
Morus
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mustard seed
Myricetin
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Myrosinase
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N-acetyl-cysteine (NAC)
NADH
Nannochloropsis
Naphthoquinones
Nardostachys
Naringenin
Nasturtium
Neem tree
Neoandrographolides
Nettle
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
Nigella seed
Night jessamine
Nimbidin
noni
nopal
nut grass
Nymphaea nouchali
okra
Oldenlandia diffusa
Oleoperin
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Oligomeric proanthocyanidins
Oligosaccharides
olive
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omega-6 fatty acids
onion
Onosma bracteatum
oolong tea
Operculina turpethum
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ophiopogon root
Opuntia streptacantha
orange
Orchis latifolia
oregano
oregon grape
oriental arborvitae
Oroxylum indicum
Osha
Osthole
Otoba
Oxindole alkaloids
Oxymatrine
Oxystelma
Oxytropis falcata
oyster mushroom
Paenibacillus polymyxa
paeoniflorin
pagoda tree
palmitoleic acid
Palmitoylethanolamide (PEA)
Pansit-pansitan
Pao Pereira
papaya
Paris polyphylla
parsley
Passionfruit
pau d'arco
paw paw
pear
Pediococcus acidilactici
Pediococcus pentosaceus
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Pentacyclic triterpenoids
peony
Pepper
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Peptides
Peptidomannan
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phellodendron amurense
phenolic compounds
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Phlebodium decumanum
phlorotannins
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Phycocyanin
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phytocannabinoids
Phytoplankton
picrorhiza kurroa
Picroside
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pineapple
Piper chaba
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Piper retrofractum
Pipsissewa
Pistachio
pistacia integerrima gall
Plantago
plantain
Platycodon
platycodon root
Plectranthus amboinicus
Pleurotus eryngii
Pluchea
Plukenetia volubilis
plum fruit
Plumbago zeylanica
Pokeweed
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Polydatin
Polygala
polygala root
Polygonatum
Polygonum
polymethoxylated flavones
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polyporous mushroom
Polyporus
polysaccharides
polyunsaturated fat
pomegranate
pomelo
poplar
Portulaca
Potentilla
prebiotic blend (proprietary)
Premna
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proteolytic enzymes
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Pseudostellaria
pu-er tea
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Pulsatilla
pumpkin
punarnava
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purple Tephrosia
purslane
Pycnogenol
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline quinone
Qin Jiao
quail egg
Queen's Delight
quercetin
quince
quinoa
radish
raspberry
ravinsara
red clover
red root
Rehmannia
rehmannia glutinosa
reishi mushroom
resveratrol
Rhabdosia rubescens
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rhizome
Rhodiola
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Rhodymenia
Rhus coraria
Rhus coriaria
Rhus glabra
riboflavin (vitamin B2)
Ribose-l-cysteine
rockweed
Rooibos
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Rosa laevigata
Rosa roxburghii
Rosarin
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rose
rose hips
rose oil
rosemary
rosmarinic acid
royal jelly
Rubia cordifolia
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S-allylcysteine
Saccharomyces boulardii
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Salidroside
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Salvia
Salvianolic acid
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Sargentodoxa
sarsaparilla
Sassafras
Savory
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Schizandrol A
Schizochytrium
Schizochytrium Oil
schizonepeta
Schizophyllum commune
Scoparia dulcis
scrophularia root
seaweed
Selaginella
selenium
Selenocysteine
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Self-Heal
Semecarpus anacardium
Sensitive Plant
sesame
Sesquiterpenes
Sete sangrias
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Shark Liver Oil
Shark oil
Shataverins
sheep's sorrel
shiitake mushroom
Shikonin
Shilajit
Sialic acid
Sichuan pepper
Sida cordifolia
Siegesbeckia
siler root
Simaruba
Sinomenium acutum
skullcap
Skunkvine
slippery elm bark
smilax
Solanum anguivi
Solanum indicum
Sophora
soursop
Soy Protein
soybean
Spanish Needle
Spatholobus
spearmint leaf
specialized pro-resolving mediators (SPMs)
Speedwell
Sphaeranthus indicus
Spikenard
Spilanthes
spinach
Spiraea
spirulina
Squalene
Stachytarpheta cayennensis
Stephania root
Stereospermum
sterols
Stilbenoid
Stillingia
strawberry
Streptococcus salivarius
streptococcus thermophilus
Sulfated polysaccharide
Sulforaphane
sulforaphane glucosinolate
suma
Sumac
Sumbul
Sweet Annie
Sweet Orange alcohol
sweet wormwood
sweetgums
Swertia
Sword Bean
Szechuan lovage
Takuna
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Tannins
Tanshinone
Taraxacum
Taraxasterol
tartarian aster
Tasmannia lanceolata
Taurine
Taxifolin
Tayuya
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Tea Tree Oil
teasel
Tejocote
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Terpinen-4-ol
Tetracyclic oxindole alkaloids
Theaflavin
Thiosulfinate
Thuja
thyme
Thymol
Thymoquinone
Thymus
Tiger Nut
Tinospora cordifolia
tocotrienols
trace minerals
Trametes
Tremella
Tribulus Terrestris
Trichopus zeylanicus
Trichosanthes
Tridax
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Turkey tail mushroom
turmeric
Turmerones
Tylophora
Tylophorine
typhonium
Typhonium flagelliforme
ubiquinol
Umckalin
Umckaloabo
Uncaria
Uraria picta
Ursolic Acid
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vegetable blend (proprietary)
Vegetable Protein
Verbascoside
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Viscum coloratum
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vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin C
vitamin D
vitamin D
vitamin D3
vitamin E
Vladimiria souliei
Wakame
Walnut
Waltheria ovata
Water Pepper
Watercress
Watermelon
Wax Gourd
wheat germ
wheat grass
Whey protein
White Dead Nettle Flower
White oak
White Poplar
White Tea
Winter Savory
Withanolides
Wogonin
Wood betony
Wulinshen
xanthium (cockleburs)
Xanthohumol
Xanthorrhizol
Xylaria nigripes
xylooligosaccharides
Yarrow
Yeast
Yellow Nut Sedge
Yerba buena
Yerba Mansa
Yerba mate
Yerba santa
Yin Chen
Yumberry
Yuzu
zanthoxylum
Zedoary
zhejiang fritillary
Zinc
Zinc
β-nicotinamide mononucleotide (NMN)

Other body systems supported by selenium

Blood
Brain
Circulatory System
Female Reproductive System
Glandular System
Hair
Heart
Immune System
Liver
Male Reproductive System
Mitochondria
Nails
Prostate
Reproductive System
Reproductive System
Skin
Testes
Testosterone
Thyroid Gland

Products containing selenium

Health Concerns

Brands

Evidence supporting the use of: Selenium
For the body system: Immune System

Table of Contents

Synopsis

Other ingredients that support Immune System

Other body systems supported by selenium

Products containing selenium

Health Concerns

Brands

Evidence supporting the use of: SeleniumFor the body system: Immune System

Table of Contents

Synopsis

Other ingredients that support Immune System

Other body systems supported by selenium

Products containing selenium

Evidence supporting the use of: Selenium
For the body system: Immune System