Evidence supporting the use of: Glycerol monolaureate
For the health condition: Impetigo

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycerol monolaurate (GML) is a monoglyceride known for its antimicrobial properties, particularly against Gram-positive bacteria. Impetigo is most commonly caused by Staphylococcus aureus and Streptococcus pyogenes, both of which are Gram-positive organisms. Several in vitro studies have demonstrated that GML disrupts bacterial cell membranes and inhibits the growth of these pathogens, suggesting a potential role for GML in the management of skin infections such as impetigo. Additionally, GML has been reported to inhibit bacterial toxin production and biofilm formation, further supporting its possible utility. Despite these promising laboratory findings, clinical evidence supporting the use of GML for impetigo in humans is limited. There are no large-scale randomized controlled trials or established clinical guidelines recommending GML as a first-line or adjunctive therapy for impetigo. Most available data are preclinical or based on animal models and in vitro studies. Thus, while GML has a scientific rationale and some experimental support for use against impetigo-causing bacteria, the overall quality and quantity of clinical evidence are insufficient to strongly validate its use. Therefore, the evidence rating is 2 out of 5, reflecting promising but preliminary scientific support rather than robust clinical validation.

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