Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Impetigo is a common superficial bacterial skin infection, primarily caused by Staphylococcus aureus and Streptococcus pyogenes. Lactoperoxidase is an enzyme found in milk and various mucosal secretions that exhibits antimicrobial properties through the generation of reactive oxygen species, particularly hypothiocyanite, in the presence of hydrogen peroxide and thiocyanate. The lactoperoxidase system has been shown in vitro to inhibit the growth of several bacteria, including those associated with impetigo.

Scientific studies, mostly laboratory-based and some limited clinical investigations, support the antimicrobial activity of lactoperoxidase against pathogens relevant to impetigo. For example, formulations containing lactoperoxidase (often with other enzymes such as lysozyme and glucose oxidase) have been included in topical products for wound care and oral hygiene, with some evidence of reduced bacterial colonization. However, robust clinical trials directly evaluating lactoperoxidase-containing products for the treatment or prevention of impetigo in humans are lacking.

Thus, while the theoretical basis and some laboratory evidence exist for lactoperoxidase’s utility in supporting impetigo treatment (hence the rating of 2), strong clinical evidence is absent. Its use is not based on tradition but on its scientifically established antimicrobial mechanism. Standard treatment for impetigo remains topical or oral antibiotics, with lactoperoxidase-containing products considered adjunctive at best, pending further research.

More about lactoperoxidase
More about Impetigo

Other ingredients used for Impetigo

Other health conditions supported by lactoperoxidase

Products containing lactoperoxidase

Metagenics Probioplex® Intensive Care Powder