Evidence supporting the use of: Alpha Galactosidase
For the health condition: Indigestion

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha-galactosidase is an enzyme that breaks down complex carbohydrates known as oligosaccharides, which are commonly found in beans, legumes, and certain vegetables (e.g., broccoli, cabbage). Humans lack sufficient endogenous alpha-galactosidase in the small intestine, so these carbohydrates often reach the colon undigested, where bacteria ferment them, leading to gas, bloating, and discomfort—hallmarks of indigestion related to such foods.

There is moderate scientific evidence supporting the use of alpha-galactosidase to reduce these symptoms. Several randomized controlled trials (e.g., Di Stefano et al., 2007, Digestive Diseases and Sciences; Suarez et al., 1994, New England Journal of Medicine) have shown that supplementation with alpha-galactosidase reduced flatulence, bloating, and gastrointestinal discomfort in healthy adults following the consumption of gas-producing foods. The enzyme is usually taken as a dietary supplement (e.g., Beano®).

However, the evidence is not universal for all types of indigestion. Alpha-galactosidase is specifically effective for symptoms related to the ingestion of oligosaccharide-containing foods. It is not indicated for indigestion stemming from other causes (e.g., peptic ulcers, GERD). Most clinical guidelines acknowledge its benefit for diet-related gas and bloating but not for broad-spectrum indigestion. No significant safety concerns have been reported for its short-term use in adults.

More about Alpha Galactosidase
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Products containing Alpha Galactosidase

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