Evidence supporting the use of: Lipase
For the health condition: Indigestion

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lipase is an enzyme that helps break down dietary fats into smaller molecules that can be absorbed by the intestine. The use of supplemental lipase (often as part of a broader "pancreatic enzyme" preparation) to support or treat indigestion, particularly when it is related to fat malabsorption or pancreatic insufficiency, is well-established in clinical practice. Scientific evidence supports its use especially in conditions such as chronic pancreatitis, cystic fibrosis, or after pancreatic surgery—situations where the body's natural production of digestive enzymes is insufficient. In these cases, patients often experience symptoms of indigestion, such as bloating, fatty stools, and abdominal discomfort due to poor fat digestion. Clinical trials and guidelines recommend pancreatic enzyme replacement therapy, which includes lipase, to alleviate these symptoms and improve nutrient absorption.

However, for general indigestion (dyspepsia) in people with normal pancreatic function, the evidence supporting lipase supplementation is much weaker. Some small studies and anecdotal reports suggest potential benefit in cases of non-specific indigestion or functional dyspepsia, but larger, well-designed trials are lacking. As a result, while lipase is scientifically validated for treating indigestion related to enzyme deficiency, its use in broader cases of indigestion is not as strongly supported. Overall, the evidence merits a moderate rating.

More about lipase
More about Indigestion

Other ingredients used for Indigestion

cutch
acid protease
activated charcoal
allspice
aloe vera
alpha-galactosidase
amylase
green chiretta
apple
apricot
artichoke
bamboo
benegut perilla (proprietary)
betel
bifidobacterium bifidum
bifidobacterium infantis
bifidobacterium longum
black pepper
radish
rice
calcium
cassia bark
chamomile
chen pi
chloride
citrus sinensis (proprietary)
cucumber
turmeric
curcumin
dandelion
melon
exo-peptidase
fennel
fenugreek
fruit and vegetable blend (proprietary)
gentian root
ginger
glucomannan
green banana
HCL
quassia
jujube
kudzu
lactobacillus gasseri
lactobacillus lactis
lactiplantibacillus plantarum
licorice root
lipase
liquid liver fractions
lovage
marshmallow
methylmethionine sulfonium chloride (vitamin U)
mint
orange
oregon grape
ox bile
pancreatin
papain
peppermint oil
pepsin
plum fruit
psyllium
quail egg
rhubarb root
schizonepeta
slippery elm bark
spearmint leaf
watermelon
xylanase
bentonite
cascara sagrada
oryza
tangerine
hyssop
cardamom
atractylodes
capsicum
Indian bael
alpinia galangal
clerodendrum indicum
ferula assafoetida
hedychium spicatum
inula racemosa
anise
punarnava
holarrhena antidysenterica
fumaria parviflora
blessed thistle
yarrow
bile salt
prickly ash
elecampane
root tuber
chrysanthemum
juniper berries
flowering quince
dogwood
dioscorea
sweetgums
queen of the meadow
caraway
anemarrhena asphodeloides
peach
wood betony
horehound
Sichuan pepper
alginic acid
sea salt
Alcohol
Avens
Apple Cider Vinegar
Actinidin
Agastache
Acidity regulator
Ambergris
Angelica
Agrimony
Amomum
Asarum heterotropoides
Alchemilla
Asafoetida
Agarwood
American Liverleaf
Appleblossom Cassia
Asam gelugor
Angostura
Arrowroot
Areca
Agrimonia pilosa
Antifoam agent
Amor seco
Aniseed myrtle
Arani
Arisaema
Asarum sieboldii
Atractylone
Betony
Buttermilk
Butter
Blue Flag
Baliospermum
Blackthorn
Broussonetia
Bicarbonate
Bayleaf
Belleric myrobalan
Blackbrush
Bistort
Big Quaking Grass
Bougainvillea
Bael
Butternut
boldo
Black Gram
Bile
black salt
Bombax
Buddha's Hand
Borassus aethiopum
Bitter principals
banana
Bassia scoparia
Belamcanda
Bottle gourd
Cumin
Centaury
Carqueja
Chervil
Coriander
Chive
Cape Aloe
Centaurium erythraea
Citron
Cantaloupe
Chlorophytum
Carvone
Cymbopogon Martini
Coca
Campylandra fimbriata
Chenopodium
Colombo
Copalchi
Cubeb
Carob
Chirata
Chaenomeles lagenaria
Carlina
Calamus
Chestnut
Colocynth
cola nut
Clerodendrum indicum
Dense Fruit Dittany
Dextrin
Dragonhead
Dill
Dianthrone
Dolichos
Dichrostachys glomerata
English Horsemint
Enzyme Blend
Elephant's Head
Fig
Goldthread
Himalayan Salt
Molasses
Phosphate Salt
Prickly Pear Cactus
Potash
Quince
Rose
Rhubarb
Squash
Sweet Orange alcohol
Vervain
Vinegar

Products containing lipase

Pure Encapsulations A.I. Enzymes
Douglas Laboratories Bilex
Integrative Therapeutics Bio-Zyme
Pure Encapsulations Digestion GB
Pure Encapsulations Digestion GB
Vitabase Digestive Enzyme
Pure Encapsulations Digestive Enzyme
Pure Encapsulations Digestive Enzymes Ultra
Pure Encapsulations Digestive Enzymes Ultra
Pure Encapsulations Digestive Enzymes Ultra with Betaine HCl
Pure Encapsulations Digestive Enzymes Ultra with Betaine HCl
Designs For Health Digestzymes™
Designs For Health Digestzymes™
Designs For Health Digestzymes™
Douglas Laboratories GI Digest
Pure Encapsulations Heartburn Essentials
Pure Encapsulations Heartburn Essentials
Vitabase Life's Essentials Plus
Integrative Therapeutics Nutrivitamin No-Iron
Designs For Health PaleoGreens®
Designs For Health PaleoGreens®
Designs For Health PaleoReds®
Pure Encapsulations Pancreatic Enzyme
Pure Encapsulations Pancreatic Enzyme
Pure Encapsulations Pancreatic VegEnzymes
Integrative Therapeutics Panplex 2-Phase
Metagenics PhytoGanix® Tropical Fruit
Designs For Health Plant Enzyme Digestive Formula
Integrative Therapeutics Similase
Integrative Therapeutics Similase
Integrative Therapeutics Similase BV
Integrative Therapeutics Similase GFCF
Integrative Therapeutics Similase-Lipo
Integrative Therapeutics Similase Sensitive Stomach
Integrative Therapeutics Similase Sensitive Stomach
Metagenics SpectraZyme® Complete
Metagenics SpectraZyme Complete
Metagenics SpectraZyme Pan 9x
Metagenics SpectraZyme Pan 9x
Metagenics SpectraZyme Pan 9x ES
Vitabase SuperZymes
Vitabase Ultra Dairy Support
Vitabase Ultra Veggie Enzymes