Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Caesalpinia crista (commonly known as fever nut or bonduc nut) has a long history of use in traditional medicine, particularly in Ayurveda, Unani, and folk systems across South Asia. Traditionally, various parts of the plant—especially seeds—have been employed to address infectious diseases, fevers, and parasitic infections. Its use is based on the belief that it possesses antimicrobial and antipyretic properties. In Ayurvedic texts, it is often recommended for the management of intermittent fevers (possibly reflecting malaria or other infectious etiologies), and as a general immune booster.

While some preliminary in vitro studies have suggested that extracts of Caesalpinia crista possess antibacterial and antifungal activity, the quality and quantity of scientific evidence remain limited. Most data are derived from laboratory experiments or animal models, and there is a lack of robust clinical trials in humans to firmly establish its efficacy and safety for treating infections. As such, its use to support or treat infections is currently justified more by traditional practice than by rigorous scientific validation. Further research, including well-designed clinical studies, is required to confirm its antimicrobial potential and therapeutic applications in humans.

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