Hygrophila (notably Hygrophila auriculata, also known as "Kokilaksha" in Ayurveda) has a longstanding use in traditional medicine systems, particularly Ayurveda, Siddha, and Unani, for supporting the body during infections and for its purported immune-supporting and antimicrobial properties. Historical texts describe its use in treating urinary tract infections, wounds, and other conditions where infection or inflammation is present. The plant is often formulated in herbal decoctions or powders intended to promote healing or to act as a general tonic in cases of "infection" as understood in traditional frameworks.

Scientific validation for these traditional uses is modest. Some in vitro and in vivo studies have demonstrated antibacterial and antifungal properties of extracts from Hygrophila auriculata, suggesting the presence of bioactive compounds such as alkaloids, flavonoids, and saponins. However, these studies are often preliminary, conducted on laboratory models, and lack robust clinical trials in humans to confirm efficacy or safety for treating infections. Modern pharmacological research does not yet substantiate its widespread use as an anti-infective agent in evidence-based medicine.

In summary, the use of Hygrophila to support or treat infections is primarily justified by traditional knowledge, with limited but suggestive preclinical research providing partial support. More rigorous human studies are needed to confirm its effectiveness and safety for this purpose.