The Pagoda tree (Styphnolobium japonicum, previously known as Sophora japonica) has a long history of use in traditional Chinese medicine and other Asian healing systems. Various parts of the tree, especially the flower buds (known as Huai Hua), have been employed for their purported medicinal properties, which include anti-inflammatory, hemostatic, and antimicrobial effects. In traditional practices, Pagoda tree extracts have been used to treat conditions such as bleeding, hemorrhoids, and infections, though the primary focus is often on vascular and anti-inflammatory benefits rather than direct antimicrobial effects. A limited number of modern scientific studies have investigated the antimicrobial potential of Pagoda tree extracts. Some in vitro research indicates that compounds such as flavonoids and alkaloids may inhibit the growth of certain bacteria and fungi. However, these studies are preliminary, often use isolated compounds at high concentrations, and have not been translated into clinical evidence or widely accepted medical treatments for infection. Overall, while there is a basis in tradition for using the Pagoda tree to support infection management, robust scientific validation is lacking. The evidence supporting its use against infection is limited and not conclusive, with a stronger historical than scientific foundation.