Evidence supporting the use of: Andrographolide
For the health condition: Infection (bacterial)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Andrographolide, a diterpenoid lactone extracted from Andrographis paniculata, has been traditionally used in Asian medicine for its broad-spectrum anti-infective properties. Scientific research in recent decades has explored its antibacterial potential, demonstrating that andrographolide exhibits in vitro activity against a range of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The proposed mechanisms include inhibition of bacterial quorum sensing, disruption of biofilm formation, and interference with bacterial cell wall synthesis. Several animal studies have shown that andrographolide can reduce bacterial load and improve survival in models of bacterial infection.

However, human clinical trials are limited and often focus on upper respiratory tract infections, where andrographolide-containing extracts (usually as part of Andrographis paniculata formulations) have demonstrated some efficacy, though direct evidence of antibacterial action (as opposed to symptomatic relief) is less robust. The evidence base is stronger for its use in acute respiratory tract infections than in systemic or severe bacterial diseases. Thus, while there is credible scientific evidence supporting its antibacterial properties in vitro and in animal models, clinical translation and validation in humans remain incomplete. Overall, its use is supported by preliminary scientific validation, but the evidence is moderate, justifying a rating of 3 out of 5.

More about Andrographolide
More about Infection (bacterial)

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Products containing Andrographolide

We currently have no products on Vitabase that contain this ingredient.