Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Berberine, an isoquinoline alkaloid found in plants such as Berberis vulgaris (barberry), has a long history of traditional use for treating infections, particularly gastrointestinal ones. However, scientific research over recent decades has provided substantial validation for its antibacterial properties. In vitro studies have consistently demonstrated that berberine exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, including common pathogens like Staphylococcus aureus, Escherichia coli, and Salmonella species.

Mechanistically, berberine disrupts bacterial cell walls and interferes with bacterial DNA replication and protein synthesis. It has also been shown to inhibit the formation of biofilms, structures that bacteria use to evade antibiotics and the immune system. Clinical studies, though fewer in number, indicate that berberine can be effective in the treatment of bacterial diarrhea, particularly that caused by Shigella and Vibrio cholerae. For example, randomized controlled trials conducted in China have reported berberine’s efficacy in reducing the duration and severity of infectious diarrhea.

While most human data focus on gastrointestinal infections, laboratory studies suggest potential for broader antibacterial applications. Nevertheless, larger and more rigorous clinical trials are needed to confirm berberine’s efficacy and safety profile for systemic or non-GI infections. Overall, the convergence of traditional use and modern research supports berberine’s role as an antibacterial agent, with a moderate-to-strong evidence base for certain infections.

More about berberine
More about Infection (bacterial)

Other ingredients used for Infection (bacterial)

Other health conditions supported by berberine

Products containing berberine

Pure Encapsulations A.C. Formula II
Integrative Therapeutics Berberine
Thorne Berberine - 1000 mg
Thorne Berberine 200 mg
Douglas Laboratories Berberine Balance
Designs For Health Berberine-Evail™
Metagenics Berberine GT
Designs For Health Berberine Synergy™
Pure Encapsulations Berberine UltraSorb
Metagenics CandiBactin BR
Metagenics CandiBactin-BR
Designs For Health GI Microb-X™
Designs For Health GI Microb-X™
Designs For Health GlucoSupreme™ Herbal
Thorne Liver Cleanse
Pure Encapsulations Metabolic Xtra
Pure Encapsulations MicroDefense with Oregano
Pure Encapsulations MicroDefense with Oregano
Integrative Therapeutics Para-Gard
Integrative Therapeutics Para-Gard
Pure Encapsulations Th1 Support
Metagenics Wellness Essentials Women's Prime Daily Packs