Divi-divi (Caesalpinia coriaria) is a plant native to the Caribbean, Central America, and northern South America. Traditionally, various parts of the plant, especially the pods, have been used in folk medicine for their purported antimicrobial properties. Ethnobotanical records indicate that indigenous and local communities have utilized divi-divi preparations, such as decoctions or poultices, to treat skin infections, wounds, and other minor bacterial complaints. The tannins present in divi-divi pods are believed to contribute to these effects, as tannins are known to possess astringent and mild antimicrobial properties. However, scientific validation for these uses is limited. While some in vitro studies suggest that extracts from Caesalpinia coriaria may inhibit the growth of certain bacteria, these findings are preliminary and do not equate to clinical efficacy in humans. No high-quality clinical trials have assessed the effectiveness or safety of divi-divi for treating bacterial infections. Thus, the support for its use against bacterial infections comes primarily from traditional knowledge rather than robust scientific evidence. Caution is advised, as reliance on traditional remedies without adequate scientific backing may not provide effective or safe treatment for bacterial infections that require medical intervention.