Evidence supporting the use of: Glyceryl monolaurate
For the health condition: Infection (bacterial)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glyceryl monolaurate (GML), also known as monolaurin, is a naturally occurring fatty acid ester derived from lauric acid and glycerol. There is scientific evidence supporting its use as an antimicrobial agent, particularly against certain bacterial pathogens. In vitro studies have demonstrated that GML possesses broad-spectrum antibacterial activity, including efficacy against gram-positive organisms such as Staphylococcus aureus (including MRSA), Streptococcus species, and some gram-negative bacteria. The mechanism of action is thought to involve disruption of bacterial cell membranes and interference with signal transduction processes necessary for bacterial growth and virulence.

GML has been used as a food preservative for its antimicrobial properties, and several peer-reviewed studies (e.g., Schlievert et al., 2019, "Glyceryl Monolaurate Antimicrobial Activity in Bacterial Pathogenesis") have investigated its potential to prevent or reduce bacterial infections in laboratory models. Some early-phase clinical research has explored its topical use for preventing infections in settings like skin and mucous membranes, but robust clinical trials in humans for systemic infection treatment are lacking.

While traditional use is limited and not well-documented, the scientific literature provides moderate evidence (rated 3/5) for its antibacterial effects in vitro and in some animal models. However, its translation to routine clinical use in treating bacterial infections in humans is not yet established, and additional research is needed to confirm efficacy and safety in this context.

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Products containing glyceryl monolaurate

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